injection of antitoxin in diphtheria by the intravenous method
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injection of antitoxin in diphtheria by the intravenous method

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Published by Lancet office in [London] .
Written in English


  • Diphtheria antitoxin.

Book details:

Edition Notes

Reprinted from the Lancet, October 6, 1906.

Statementby A.O. Bisson.
The Physical Object
Pagination16p. ;
Number of Pages16
ID Numbers
Open LibraryOL21880840M

Download injection of antitoxin in diphtheria by the intravenous method


the injection of antitoxin in diphtheria by the intravenous method. Previous Article LONDON (ROYAL FREE HOSPITAL) SCHOOL OF MEDICINE FOR Cited by: 2. INTRAMUSCULARLY INJECTED WITH DIPHTHERIA ANTITOXIN, DIPH-THERIA TOXIN HAVING BEEN INJECTED 91/2 HOURS BEFORE. NUMBER OF ANIMALS IN EACH GROUP 65; TOXIN DOSE 5 M.L.D.; ANTITOXIN DOSE 1 A.U. would lead to fewer deaths and provide information about the effect of the method of injection on the paralyses which appear in a later stage of diphtheria.   The benefits of the antitoxin treatment of diphtheria are well recognized. From to in New York City the deaths from diphtheria per hundred thousand of population ranged from to and from to the combined diphtheria deaths in the larger European and American cities from to per hundred thousand population, while following the general use of diphtheria Author: Edwin Henry Schorer. Proper Use. Drug information provided by: IBM Micromedex Dosing. The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label.

Diphtheria Antitoxin (Equine) Connaught. Antitoxin. Indications And Clinical Uses: For the treatment of suspected or confirmed cases of diphtheria. Precautions: Before administering any serum or antitoxin to a patient, physicians are well advised to ascertain whether the patient has a history of asthma, or hay fever, and particularly, whether the patient suffers distress when in proximity to.   Uses for diphtheria antitoxin. Diphtheria antitoxin is used to prevent and/or treat diphtheria infection in persons exposed to the disease. Although rare in the U.S., diphtheria is a serious disease that can cause life-threatening illnesses. Diphtheria is transmitted through contact with an infected person or a carrier of the disease. Note: An intramuscular injection of International Units of diphtheria antitoxin will protect any person, regardless of age, who has been exposed to diphtheria {06}. The protection so conferred is, however, of a temporary nature; if danger of infection persists after two weeks, an additional International Units of diphtheria antitoxin should be administered {06}. Although there is no specific information comparing use of diphtheria antitoxin in children with use in other age groups, this medicine is not expected to cause different side effects or problems in children than it does in adults. Geriatric. Many medicines have not been studied specifically in older people.

Diphtheria antitoxin (DAT) is used to prevent or treat diphtheria by neutralizing the toxins produced by Corynebacterium diphtheriae. DAT is a sterile, aqueous solution of the refined and concentrated proteins, chiefly globulins, containing antibodies obtained from the serum of horses that have been immunized against diphtheria toxin. group and a DT-injected group. Diphtheria intoxication was simulat-ed in the rabbits by intravenous injection of DT. The myocardium of the rabbits and the female subject were harvested for histopathologic and immunofluorescence examination. A mouse monoclonal anti-DT antibody was used for the immunofluorescent antibody method. The liberal use of antitoxin subcutaneously and intramuscularly in the treatment of diphtheria has been a routine precedure for thirty years, with a great reduction in the mortality as compared with preantitoxin days. Its use intravenously, however, has not been a common or general practice. The child was given an injection of antitoxin, and this was followed by a severe and protracted illness. Very significant, in this connection, are certain utterances of Dr. William Osler in his "Practice of Medicine. " He says, on page " Of the sequelae of diphtheria, paralysis is by far the most important.